Analysis of the algorithm: From kernels to backup genes.

Kernelization section

The algorithm transformed the semantic similarity matrix to make it compatible with a kernel. Once this was done for each network and kernel type, it was integrated by kernel type. Below there is a general analysis of the properties of each matrix in the different phases of the process.

Annotations properties

Table 1. Annotation files descriptors

Net Min Max Average Standard_Deviation
biological_process 1 134 6.9968818026710595 11.431432499773674
cellular_component 1 40 4.162222345933308 5.25157343549579
disease 1 21 2.2250479846449136 2.909050012799259
genetic_interaction 1064.0 1070.0 1069.7655871845109 1069.7662188776321
molecular_function 1 26 3.028670320161523 3.71561924352452
pathway 1.0 191.0 4.003825833485152 8.704590940604282
phenotype 1 335 31.549734094937957 46.988832336933186
protein_interaction 1.0 729.0 29.8386134923593 54.03869234947398

Matrix properties

Table 2. Similarity matrixes

Net Matrix_Dimensions Matrix_Elements Matrix_Elements_Non_Zero
biological_process_sim 16997x16997 288898009 262330240
cellular_component_sim 17963x17963 322669369 322651406
disease_sim 4168x4168 17372224 16578192
genetic_interaction_sim 17354x17354 301161316 1862674
interaction_sim 16098x16098 259145604 479348
molecular_function_sim 17335x17335 300502225 300484890
pathway_sim 3828x3828 14653584 159182
phenotype_sim 5077x5077 25775929 25770852
protein_interaction_sim 16098x16098 259145604 479348

Table 3. Filtered similarity matrixes

Net Matrix_Dimensions Matrix_Elements Matrix_Elements_Non_Zero
biological_process_sim 16997x16997 288898009 262330240
cellular_component_sim 5828x5828 33965584 33959756
disease_sim 4006x4006 16048036 15309960
molecular_function_sim 13145x13145 172791025 172777880
pathway_sim 3423x3423 11716929 159134
phenotype_sim 4728x4728 22353984 22349256

Table 4. Uncombined kernel matrixes

Net Kernel Matrix_Dimensions Matrix_Elements Matrix_Elements_Non_Zero
biological_process ct 16997x16997 288898009 288898009
biological_process el 16997x16997 288898009 288898009
biological_process ka 16997x16997 288898009 262347237
biological_process rf 16997x16997 288898009 288898009
cellular_component ct 5828x5828 33965584 33965584
cellular_component el 5828x5828 33965584 33965584
cellular_component ka 5828x5828 33965584 33965584
cellular_component rf 5828x5828 33965584 33965584
disease ct 4006x4006 16048036 16048036
disease el 4006x4006 16048036 16048036
disease ka 4006x4006 16048036 15313966
disease rf 4006x4006 16048036 16048036
genetic_interaction ct 17354x17354 301161316 297804049
genetic_interaction el 17354x17354 301161316 293368612
genetic_interaction ka 17354x17354 301161316 1880028
genetic_interaction rf 17354x17354 301161316 293368612
molecular_function ct 13145x13145 172791025 172791025
molecular_function el 13145x13145 172791025 172791025
molecular_function ka 13145x13145 172791025 172791025
molecular_function rf 13145x13145 172791025 172791025
pathway ct 3423x3423 11716929 11703245
pathway el 3423x3423 11716929 8605893
pathway ka 3423x3423 11716929 162557
pathway rf 3423x3423 11716929 8605893
phenotype ct 4728x4728 22353984 22353984
phenotype el 4728x4728 22353984 22353984
phenotype ka 4728x4728 22353984 22353984
phenotype rf 4728x4728 22353984 22353984
protein_interaction ct 16098x16098 259145604 259081193
protein_interaction el 16098x16098 259145604 252047984
protein_interaction ka 16098x16098 259145604 495446
protein_interaction rf 16098x16098 259145604 252047984

Table 5. Integrated kernel matrixes

Integration Kernel Matrix_Dimensions Matrix_Elements Matrix_Elements_Non_Zero
integration_mean_by_presence ct 19521x19521 381069441 366285074
integration_mean_by_presence el 19521x19521 381069441 364427222
integration_mean_by_presence ka 19521x19521 381069441 293258900
integration_mean_by_presence rf 19521x19521 381069441 364427222
mean ct 19521x19521 381069441 366285074
mean el 19521x19521 381069441 364427222
mean ka 19521x19521 381069441 293258900
mean rf 19521x19521 381069441 364427222

Weight values